HYALO4 Start

A synergic combination for promotion of healing
and wound bed preparation
HYALO4 Start
HYALO4 Start
Hyaluronic Acid Sodium Salt 0.2%
Collagenase (from Vibrio Alginolyticus)
Oinment | 30 g Tube for topical use
What is Hyalo4 Start ?
Hyaluronic Acid and Collagenase promote Healing of Chronic Wounds and prepare the Wound Bed.
Hyalo4 Start is a fluid ointment for topical use containing sodium hyaluronate obtained by bacterial fermentation, as the principal component, and bacterial collagenase obtained from a non-pathogeneic Vibro alginolyticus strain, as an incorporated medicinal substance. Hyalo4 Start allows the preparation of the wound bed, thanks to the hydrating properties of hyaluronic acid that promotes the natural repair process and protects the new viable tissue. In fact the process of cicatrization of the lesion takes place more rapidly in a moist enviroment. The bacterial collagenase assist in the wound bed preparation.
What is Hyalo4 Start indicated for?
Local management of chronic wounds. In particular, it is intended to provide an optimal moist enviroment and wound bed preparation that supports the natural process.
Pressure Sores
Pressure Sores
Vascular Ulcers of Legs
Vascular Ulcers of Legs
Diabetic Ulcers
Diabetic Ulcers
Hyalo4 Start: advantages
  • Hyalo4 Start allows the preparation of the wound bed, thanks to the hydrating properties of hyaluronic acid that promotes the natural repair process and protects the new viable tissue.
  • The collagenase in Hyalo4 Start is 99% pure. The absence of non-specific protease entails a totally specific action with no bothersome dermatitis around the wound.
  • Hyalo4 Start is very fluid, smooth, and simple to apply, with nether discomfort non pain
How does Hyalo4 Start work?
Hyaluronic acid and collagenase play a synergic role to promote healing.
Hyaluronic Acid
  • Creates a moist enviroment for optimal tissue repair
  • Generates microenvironment supporting the secretion of growth factors, proliferation and migration of fibroblasts, endothelial cells, keratinocytes and angiogenesis
  • Favors the ideal conditions for orderly arrangement of collagen
Collagenase (from Vibrio Alginolyticus)
  • Highly purified enzyme, degrades fibrinous and necrotic tissue contributing to wound bed preparation
  • Selective removal of necrotic tissues while preserving perilesional skin and healthy tissue
How to use Hyalo4 Start ?
Step 1
Clean the wound using physiological solution.
Step 2
Apply a 2 mm layer of Hyalo4 Start once a day, or according to the indications of the healthcare professional. A sterile spatula can be used for easier application.
Step 3
Cover the wound with a non-stick medication such as a non-adherent dressing.
Step 4
Cover the treated area with a sterile dressing to assure an appropriate contact.
Hyalo4 Start: clinical evidence
Hyalo4 Start: case studies
Chronic Pressure Ulcer

Patient: Female 97 years old.

  • chronic pressure ulcer on the external malleolus in the right leg
  • Approximately 3x2 cm

T= 0

The wound bed is covered with fibrin, with signs of granulation. The margins are clear but with signs of maceration. The wound is cleansed with physiological solution and then Hyalo4® Start - Ointment (collagenase and hyaluronic acid) is applied to remove the fibrin and stimulate the healing process. As secondary medication a thin hydrocolloid is used. Medication applied every four days.

T= 1 (42 days)

The image shows the reduced size of the wound, margins are clear vital and contracting, no signs of maceration and a clean and cleansed bed. Slight hyper-granulation on the wound bed. Given the results obtains so far, it is decided to continue with Hyalo4® Start - Ointment (collagenase and hyaluronic acid) to keep the wound bed clean and to stimulate the healing process. Secondary medication with thin hydrocolloid. Medication changed every four days.

T= 2 (54 days)

Wound well on the way to healing, with minimum size with respectto the beginning, vital and well cleansed bed, vital margins in reepithelialisation, healthy skin around the wound. It is decided to apply a thin hydrocolloid until final healing.


© Fidia Farmaceutici S.p.A.
Via Ponte della Fabbrica 3/A - 35031 Abano Terme (PD) - Italy
Tel. (+39) 049 8232221 - 2222 Fax (+39) 049 810653
Cap. Soc. € 36.120.000 int. vers. - C.C.I.A.A. PD n. 80793 - Iscr. Reg. Imp. PD
Cod. Fisc. e P. IVA 00204260285

Follow us