HYALO4 Regen

Bioactive dressing for lesions with delayed healing
HYALO4 Regen
HYALO4 Regen
Hyaluronic Acid Sodium Salt 2.5%
Heterologous Type I Horse Collagen
Pad | 5x5cm and 10x10cm for topical use
What is Hyalo4 Regen ?
Creates the ideal conditions for kick-starting wounds with delayed healing
Hyalo4 Regen is a bioactive dressing consisting of heterologous type I horse collagen and hyaluronic acid, in the form of lyophilized, sterile spongy pads, easily adaptable to the application area, adjuvant in the physiological process of wound healing.
What is Hyalo4 Regen indicated for?
Acute and chronic lesions, from moderately to highly exuding wounds
Pressure Sores
Pressure Sores
Vascular Ulcers
Vascular Ulcers
Diabetic Foot Ulcers
Diabetic Foot Ulcers
Chronic Skin Ulcers with Delayed Healing
Chronic Skin Ulcers with Delayed Healing
Surgical Lesions
Surgical Lesions
First- and Second-Degree Burns
First- and Second-Degree Burns
Wounds Originating from General and Specialized Surgery
Wounds Originating from General and Specialized Surgery
Hyalo4 Regen: advantages
  • Creates the ideal conditions for treating acute and chronic lesions, especially moderate to highly exuding wounds.
  • Plays a crucial role in rebuilding tissue architecture after injury
  • Easily adaptable to the application area
  • Efficacy and safety supported by clinical experience.
How does Hyalo4 Regen work?
A synergic combination of Hyaluronic Acid and Collagen into a dressing pad
Hyaluronic Acid
  • Maintains a moist environment, favouring also the ideal conditions for orderly arrangement of collagen
  • Generates microenvironment supporting the secretion of growth factors, proliferation and migration of fibroblasts, endothelial cells, keratinocytes and angiogenesis
Type I horse collagen
  • Highly pure, not immunogenic
  • Supports dermal structure during the repair phase by creating a fibril net
  • Favors the anchoring and orientation of fibroblasts and formation of new tissue
  • Local hemostatic action
How to use Hyalo4 Regen ?
Step 1
Pre-treat the wound bed and cleanse the lesion with a humid gauze soaked in saline solution, dabbing it repeatedly.
Step 2
After the process of debridement to remove any purulent material and/or necrotic debris, apply the smooth surface of the pad on the wound. In case of low exudate moisturize the pad with saline solution.
Step 3
It is recommended to apply the dressing every 3-4 days or at smaller intervals, according to the wound exudate. To maintain an ideal humid microclimate cover with a more or less absorbent secondary dressing, depending on the level of exudate, and apply a bandage.
Step 4
The pad can be removed by irrigating the wound with physiological solution. Any residues do not need removing, since the product gellifies with exudate and it is perfectly biocompatible.
Hyalo4 Regen: clinical evidence
Hyalo4 Regen Pad in DFU treatment:
An Observational Study
Hyalo4 Regen: case studies
  • Burn Lesion

    Patient: 77-year-old female.
    Diagnosis and treatment:

    • After a month of ineffective medication with pomades, total escharotomy of the sole of the foot was performed
    • Hyalo4® Regen

    T= 0

    Post-burn lesion; total escarectomy of the sole of the foot was performed after 1 month of ineffective topical treatment.

    T= 7 days

    Subsequently, biweekly dressings with washes and polyesanide gels (prontosan) were carried out until a well granulated surface was obtained.

    T= 25 days

    The treatment of Hyalo4® Regen was initiated until healing of the surface is achieved.

    Ongoing healing

  • Acute compartment syndrome in lower extremity musculoskeletal trauma

    Patient: 51-year-old male.
    Crushing trauma with popliteal artery injury.
    Diagnosis and treatment:

    • Femoral popliteal bypass surgery
    • 2x decompressive fasciotomy
    • Hyalo4® Regen and Hyalo4 Control

    T= 0

    The patient arrived in the consulting department following a crushing trauma with popliteal artery injury for an accident at work (lower left limb 1-3 distal). He was sent to the operating room where he underwent to bypass (poplite femor). The day after, compartmental syndrome was found, for which 2 decompression fasciotomies were performed: a minimal fasciectomy above malleolar-external and a more relevant one at the height of the inner calf. When the syndrome seems to have resolved, the fasciotomy was closed with sutures at the most distal points.

    T= 1 (35 days)

    The lesion was treated with negative pressure. It was decided to suspend the negative topical pressure and to start the medications with Hyalo4® Regen and Hyalosilver.

    T= 2 (40 days)

    After a consultant with a plastic surgeon the patient was put on the operating list for grafting. The day after the patient was transferred to another hospital to perform an intensive physiotherapy cycle. The medication indicated above was continued.

    T= 3 (64 days)

    The patient goes to the plastic surgeon for a control visit, but he refused the intervention because the area was considerably reduced. Thanks to the Hyalo4® Regen medication, the lesion has significantly improved. The patient avoided skin graft surgery and the healthcare company did not face any additional patient management costs.

    Treatment with Hyalo4 Regen


© Fidia Farmaceutici S.p.A.
Via Ponte della Fabbrica 3/A - 35031 Abano Terme (PD) - Italy
Tel. (+39) 049 8232221 - 2222 Fax (+39) 049 810653
Cap. Soc. € 36.120.000 int. vers. - C.C.I.A.A. PD n. 80793 - Iscr. Reg. Imp. PD
Cod. Fisc. e P. IVA 00204260285

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